Cortical bone viscoelastic damping assessed with resonant ultrasound spectroscopy reflects porosity and mineral content

نویسندگان

چکیده

Viscoelasticity is an essential property of bone related to fragility, which altered in aging and disease. Bone viscoelastic behavior attributed several mechanisms involving collagen mineral properties, porosities, hierarchical tissue organization. We aimed assess the relationships between cortical damping measured with Resonant Ultrasound Spectroscopy (RUS), microstructural compositional characteristics. 52 specimens from femur 26 elderly human donors. RUS provided a shear coefficient at frequency order 150 kHz. The characteristics structure vascular pore network density were using synchrotron radiation high-resolution computed tomography (SR-μCT). Fourier transformed infrared microspectroscopy (FTIRM) was used quantify mineral-to-organic phase ratio, maturity, crystallinity, maturity. Cross-links quantified biochemistry. Viscoelastic found increase porosity (r=0.68), decrease degree mineralization extravascular matrix (r=−0.68), marginally affected by collagen. built multilinear model suggesting that when controlled, variation content explains small additional part variability damping. work supports consideration viscoelasticity measurement as potential biomarker fragility provides documentation its determinants range rarely investigated.

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ژورنال

عنوان ژورنال: Journal of The Mechanical Behavior of Biomedical Materials

سال: 2021

ISSN: ['1751-6161', '1878-0180']

DOI: https://doi.org/10.1016/j.jmbbm.2021.104388